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A protein used in insecticides may be worsening cockroaches, fruit flies and other pests -- but only by boosting their resistance. Despite mortality from DDT, some flies survive by revving up an enzyme involved in toxin resistance. This adaptation makes bugs not just deadlier, but harder to control.
When pests evolve resistance to insecticides, its usually because a gene altered their response to the poison. But new research shows that fruit flies surviving DDT exposure dont survive because theyve changed their target — they become winners by revving up an enzyme involved in toxin resistance. This adaptation allows them not just to survive, but thrive, becoming even stronger pests.
Published in PLOS Pathogens, the study documents how resistance to DDT drives dramatic increases in a detoxification enzyme called CYP6A2. This protein helps break down DDT in fruit flies, but rather than disabling its effects, the change enhances resistance without fully neutralizing the toxin — effectively boosting survival. The result? Resistant flies not only survive exposure but reproduce more successfully, accelerating their spread.

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