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Sat, 02 May 2026 06:19:47 +0000

IgE, mast cells, basophils, and eosinophils are essential components of allergic inflammation. Antigen-specific IgE production, with subsequent fixation of IgE to FcRI receptors on mast cells and. Through complex signaling and crosstalk, eosinophils, basophils, and mast cells work in unison to release a variety of mediators that activate neighboring eosinophils/basophils/mast cells,. Eosinophils, basophils, and mast cells are effector cells of the innate immune system and generally associated with type 2 immunity in response to allergens and helminth infections. Basophils, eosinophils and mast cells were first recognized by Paul Ehrlich in the late 19th century. These cells have common, but non-redundant roles, in the pathogenesis of allergic diseases.